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Colloidal Gold electron microscope

wallpapers News 2021-12-30
Colloidal gold and various derivatives have long been the most widely used antigen tags in electron microscopy. Colloidal gold particles can be attached to many traditional biological probes, such as antibodies, lectins, superantigens, glycans, nucleic acids, and receptors. Particles of different sizes are easily distinguished in electron micrographs, allowing multiple labeling experiments to be performed simultaneously
In addition to biological probes, gold nanoparticles can be transferred to a variety of mineral substrates, such as mica, monocrystalline silicon, and atomic plane gold (III), for observation under atomic force microscopy (AFM)
Colloidal Gold drug delivery system
Colloidal Gold nanoparticles can be used to optimize the biological distribution of drugs in diseased organs, tissues, or cells to improve and target drug delivery. Nanoparticle-mediated drug delivery is feasible only if drug distribution is inadequate. These cases include unstable drug targeting (proteins, siRNA, DNA), delivery to difficult sites (brain, retina, tumors, organelles), and drugs with serious side effects (e.g., anticancer drugs). The performance of nanoparticles depends on particle size and surface function. In addition, drug release and particle disintegration can vary from system to system (e.g., ph-sensitive biodegradable polymers). The optimal nano delivery system ensures the correct time and duration of the active drug at the site of action at concentrations higher than the minimum effective concentration (MEC) and lower than the minimum toxic concentration (MTC)
Gold nanoparticles are being investigated as a carrier for drugs such as paclitaxel. The use of hydrophobic drugs requires molecular encapsulation, and nanoparticles are particularly effective in avoiding the reticuloendothelial system.
Colloidal Gold tumor detection
In cancer research, colloidal gold can be used to target tumors and provide in vivo surface-enhanced Raman spectroscopy (SERS) detection. The gold nanoparticles are surrounded by A Raman detector that emits 200 times more light than quanta. It was found that the Raman records were stable when the nanoparticles were coated with mercapto-modified polyethylene glycol. This allows compatibility and internal circulation. To specifically target tumor cells, polyethoxylated gold particles bind to antibodies (or antibody fragments, such as single-chain antibodies) to antagonize epidermal growth factor receptors, which are sometimes overexpressed in certain types of tumor cells. Using SERS, these peg gold nanoparticles were able to detect the location of tumors
Gold nanoparticles accumulate in tumors due to leakage of tumor vascular systems and can be used as contrast agents for enhanced imaging. Skin cancer detection in mouse models using a short pulse laser in a time-resolved optical tomography system. The results show that intravenous injection of spherical gold nanoparticles can widen the time profile of the reflected light signal and enhance the contrast between the surrounding normal tissue and the tumor

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