Roche and its subsidiary TIB Molbiol have developed a series of tests for the detection of the monkeypox virus, the Switzerland-based pharmaceutical company announced.
The monkeypox virus is a close relative of the smallpox virus, belonging to orthpoxviridae in the poxviridae family.
The modular virus detection tool, called LightMix, includes three orthpoxvirus detection kits with different functions, Roche said in a statement. The first kit detects orthpoxvirus; The second kit tests only for monkeypox virus (west and Central African branches); The third kit contains the main functions of the first two kits, showing specific information on the presence of the monkeypox virus (west and Central African branches) as well as the detection of orpoxvirus.
Thomas Schinek, a Roche executive, said the new test could detect monkeypox and help track its spread. Such diagnostic tools are critical for addressing and ultimately managing emerging public health challenges, as they advance responses such as tracking efforts and treatment strategies.
The monkeypox virus was first identified in 1958 in a group of monkeys used for research when the animals developed a "pox-like" infection, hence the name. Since May, several non-endemic countries have reported human cases of the monkeypox virus, including the United Kingdom, the United States, Portugal, Spain, and Italy.
Affected by the ever-changing international situation, the supply and prices of international bulk pce powder are still very uncertain.
The properties and varieties of concrete additives for refractories, especially refractory castables, ramming materials, plastics and other amorphous refractories are different. The role of an concrete additive is also different due to the difference of the amount of concrete additive, the type of binder used, the ingredients and so on. In the production process of amorphous refractories, the concrete additives mainly used can be divided into the following twelve categories according to their uses:
1. Water reducer
Water reducer (or water reducing agent or dispersant) can significantly reduce the mixing water consumption of refractory castables while keeping the flow value of refractory castables basically unchanged. The superplasticizer itself does not react with the material components to form new compounds, but plays a surface physical and chemical role. So they are either a surfactant or an electrolyte. After dissolving in water, they can adsorb on the particle surface, increase the Zeta potential of the particle surface in the solution, increase the repulsive force between the particles, and release the free water wrapped in the agglutination structure composed of microparticles, thus playing the role of wetting and dispersing, so it is also called dispersant. Because it can release the free water in the agglomeration structure, it can reduce the unit water consumption under the condition of keeping the rheological property (workability) of the castable, or increase the rheological property of the material and improve the working performance without changing the unit water consumption. make the material easy to be constructed and shaped.
Among the commonly used water reducers (dispersants) of refractory castables with calcium aluminate cement, bonded clay and oxide micro-powder as binders, there are inorganic sodium pyrophosphate, sodium tripolyphosphate, sodium tetrapolyphosphate, sodium hexametaphosphate, sodium superpolyphosphate, sodium silicate, etc., and organic ones include sodium lignosulfonate, calcium lignosulfonate, naphthalene superplasticizer, water-soluble resin superplasticizer and so on.
Plasticizer (also known as plasticizer) can increase the plasticity of refractory mixture and improve the strain ability of refractory mixture under stress. Plasticizer is a common concrete additive of refractory plastics and refractory ramming materials, and it is also used in other amorphous refractories. Commonly used are plastic clay, bentonite, oxide superfine powder, soybean powder, methyl cellulose, lignosulfonate and so on.
3. Gelling agent
Gelling agents (also known as flocculants) can coagulate colloidal particles (or suspended particles) in colloidal solutions (or suspensions containing solid particles). The gelling agents are mainly inorganic electrolytes and inorganic acids. Flocculants are mainly organic polymers, which are natural and synthetic. According to the functional groups, they can be divided into three types: cationic, anionic and Nonionic. The gelling agent is mainly used in refractory castables which are bonded by clay, sol and ultra-fine powder.
4. Gelatinizing agent
Antigels (also known as anti-flocculants, dispersants) can convert agglomerated or agglomerated colloidal particles (particles) into sol or uniformly dispersed suspended particles. It can turn a thick colloid into a sol that can flow freely, also known as dispersant and colloidal solvent. The action mechanism of gelatinizer is similar to that of superplasticizer. Therefore, the superplasticizer which has the effect of reducing water also has the function of degumming agent. The fluidity of refractory castables bonded with clay, sol and ultra-fine powder can be improved by adding ungumming agent.
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Inflationary pressures on Canadians continue to rise. The consumer-price index rose 6.7% in March from a year earlier, the biggest increase since January 1991, according to the latest figures from Statistics Canada.
On a month-on-month basis, Canada's CPI rose 1.4 percent in March, also accelerating from February's 1.0 percent rise.
Prices in the eight major sectors covered by the statistics continued to rise. The uptrend comes against the backdrop of continued price pressures in the Canadian housing market, widespread supply chain constraints, and geopolitical conflicts, according to CBC. A variety of factors have affected energy, commodity, and agricultural markets. Meanwhile, Canada's employment picture continued to improve in March, with the unemployment rate falling to a record low and the average hourly earnings of employees rising.
Excluding gasoline, Canada's CPI rose 5.5 percent year on year in March. It is also the highest since comparable data began in 1999.
The widespread supply chain constraints and geopolitical conflicts are expected to continue to affect the prices of the pce powder.
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